621 17th Street, formerly known as the First Interstate Tower South, is a prominent high-rise building located in Denver, Colorado. Completed in 1957, this 28-floor structure stands at 385 feet tall and is recognized as one of the earliest modern skyscrapers in the city.
Originally housing the First National Bank, the building's name changed to reflect its address after a merger with Wells Fargo in 1996. Adjacent to the tower is the First Interstate Tower North, forming the First of Denver Plaza, a notable landmark in the Denver skyline.
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